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Allopurinol Helps to Prevent Gout Attacks

Treatment Option for People With Chronic Gout

Allopurinol (brand names Aloprim and Zyloprim) is a drug that belongs to a class of medications called xanthine oxidase inhibitors. Allopurinol is prescribed for the treatment of chronic gout and is used to prevent rather than treat gout attacks.

The medication works by blocking uric acid production. Uric acid is a waste product normally present in the blood as a result of the breakdown of purines.

Excessive amounts of uric acid can cause crystals to form in the joints, which can lead to gout.

When Is Allopurinol Prescribed?

Allopurinol is prescribed to prevent chronic gout attacks, manage high uric acid levels caused by cancer medications, and to treat kidney stones. There are also a handful of off-label uses for which your doctor may prescribe allopurinol.

What Is the Usual Dosage of Allopurinol?

Allopurinol is available as a 100 mg tablet. It is typically taken once or twice daily, usually following a meal. The dose may be increased gradually at weekly intervals in increments of 100 mg/day as needed to achieve the optimal serum uric acid level. Usual dosage range is 200 to 300 mg/day for mild gout; 400 to 600 mg/day for moderate to severe tophaceous gout. The maximum daily dose is 800 mg/day.

Are There Special Instructions?

People are advised to follow the prescribing instructions precisely.

It is common for the starting dose of allopurinol to be low and gradually increased. Noticeable benefit from taking allopurinol may take months. In fact, during the first few months of use, the medication may actually increase the number of gout attacks. Eventually, allopurinol will prevent gout attacks.

In the interim, colchicine should be prescribed to reduce the risk of gout attack. Do not stop taking allopurinol even if you're feeling well.

Should Some People Not Take Allopurinol?

People with a known allergy to allopurinol obviously should not take the medication. People who take any of the following medications should tell their doctor because they may require a dose adjustment:

• Amoxicillin
• Ampicillin
• Coumadin
• Cytoxan
• Purinethol
• Diabinese
• Diuretics
• Immunosuppressants
• Other gout medications

Allopurinol has been associated with hypersensitivity reactions, especially in certain populations, such as  Koreans with stage 3 or worse chronic kidney disease, Han Chinese, and people of Thai descent. People with suspected hypersensitivity in the aforementioned populations can be tested for HLA-B*5801 prior to initiating treatment with allopurinol. 

What Common Side Effects Can Occur With Allopurinol?

Allopurinol can cause upset stomach, diarrhea, and drowsiness. Rash is one of the more common side effects and can occur even after months or years of treatment with allopurinol.

Are There Severe Side Effects Associated With Allopurinol?

Uncommon side effects that are more severe, if they occur, include:

• Hypersensitivity reactions

• Itching
• Blood in urine or pain when urinating
• Eye irritation
• Swelling around mouth or lips
• Signs of infection
• Loss of appetite or unexpected weight loss

What Special Warnings and Precautions Are Associated With Allopurinol?

People are advised to drink plenty of water daily (unless a doctor instructs otherwise). Alcoholic drinks may decrease the effectiveness of allopurinol. Drinks or supplements containing vitamin C may be problematic in large quantities. Excessive vitamin C and allopurinol can combine to make urine acidic and cause kidney stones. Patients with kidney problems may need a dose adjustment for allopurinol.

Are There Special Instructions for Pregnant or Nursing Women?

If you are pregnant, breastfeeding, or planning on becoming pregnant, discuss allopurinol with your doctor. Few reports of allopurinol use during pregnancy exist. Although no adverse fetal outcomes associated with allopurinol have been noted in humans, allopurinol should only be used after weighing benefit to the patient versus risk to the fetus.

How Is Effectiveness of Allopurinol Assessed?

Certain laboratory tests are periodically ordered which help to determine if the drug is working.

_Sources:

_{Drug Information: Allopurinol. MedlinePlus. Revised 02/11/2012.
https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682673.html}

_{Allopurinol: Drug Information. Lexicomp. UpToDate.com. Accessed 06/17/2016.
https://www.uptodate.com/contents/allopurinol-drug-information?source=search_result&search=allopurinol&selectedTitle=1%7E148}

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Health Benefits of Quantumin Plus

Why you should use Quantumin Plus? These are few of the very many reasons why people continuously use Quantumin Plus.

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* Energizes and balances electrical potential at the cellular level.
* Detoxifies the different organs of various chemicals like
pesticides, radioactive elements, and other pollutants.
* Alkalinizer to neutralize body acids, stomach acids.
* Chelates heavy metals like lead, mercury, cadmium, etc.
* Increases the amount of oxygen in the blood.
* Quantumin Plus Transports nutrients right into the cells.

* Increases absorbability of other nutrients and medicines.
* Promotes mental clarity and sense of well being.
* Improves enzyme production and activity.
* Quantumin Plus Contains antibiotic effects without developing resistant strains
even on prolonged use.

* Neutralizes free radicals.
* Normalizes the immune system function.
* Quantumin Plus Helps fight common illnesses and chronic disease like:

Acidosis/GERD
Allergies/ Eczema
Anemia
Arteriosclerosis
Attention Deficit Disorder (ADD)
Back Pain
Body Odor
Cancer/ Tumors
Cardiovascular Disease
Cataract/ Glaucoma
Constipation
Tuberculosis
UTI
Varicose Veins
Vertigo
Depression
Diabetes
Fibromyalgia
Gallstone
Hypertension
Impotency
Kidney Stones
Kidney Failure
Leukemia
Liver Cirrhosis/ Tumor
Memory Loss
Warts
Wrinkles
Viral Disease
Common Colds/ Flu
Headaches
Migraines
Muscle Pains
Nerve Disorder
Osteoporosis
Pancreatitis
Parkinson’s disease
Prostate Problems
Fungal Diseases
Stress/ Anxiety
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Multiple Sclerosis
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SHARE 4 Reasons to make your Business Online

Look around. What do you notice?

Everyone’s on the phone — watching their favorite movies, browsing things to purchase from online stores or reading viral posts on Facebook. People, nowadays, heavily rely on technology for the best-selling item in this era: information. And you know how much power information holds. It can influence or change people’s behavior the way you, as a digital marketer, want to.

While the traditional way of marketing using flyers, billboards, print ads, and television and radio ads is still prevalent and effective up to these days, digital marketing can be a better alternative, especially for startups. It’s time you use your social media for something bigger than socializing or whatever it is you do on your devices or computers. Here are more reasons to convince you that you need to go digital today if you want your business to succeed!

WIDER REACH OF AUDIENCE

According to the Internet Live Stats, 45 million people or almost half of the Philippine population are internet users. Yes, it hurts for every traditional marketer to admit that most people are online today. Everyone from class A to D has an access to the internet. Imagine that number of people as potential markets. If you succeed in winning their trust in buying what you’re selling, it won’t be long before you become the next business tycoon.

CONVENIENCE

Here’s a thought, you have a business that eyes a large number of the market. How do you reach these people? Have you ever experienced approaching people in busy public places and passing them your promotional flyers? Certainly, most people will just ignore you. Sure, one might be kind enough to take what you’re giving, but chances are, he will just throw it out or fold it in.

With marketing online, you can be at the comfort of your home! Just an internet connection and whatever device you’re using, you can be wherever you want and still promote your business.

CHEAPER TO NO FEES

Did you know that the average 15-second television ad costs hundreds of thousands of pesos? Same with a newspaper ad and billboard, only to be passed by and be looked at for a few seconds. These traditional advertising still offers great exposure, but its cost is just too much for an aspiring entrepreneur.

So, how much will it cost you to go digital? You need to pay for a regular internet connection, or an hour or two for the access at the computer shop, which are minimal, you can surely afford. Let’s say you can get the same positive results by using traditional and digital marketing, will you go for the one that saves bucks? Of course!

COMPETITIVENESS

The business competition is always tough; you need to create a recall to stand out. People should remember your brand and your products. You can do this by consistently communicating with your consumers about what you offer and how it can help improve their way of life.

Today, small businesses utilize social media to market products or services. You’ll lose the competition if you don’t recognize the value of digital marketing.

If you want to learn more about digital marketing, attend Royale’s FREE training about effective online marketing. Aside from creating social media accounts, you will also pick up some tips on how to maximize your exposure online without taking up so much of your time and money.

It’s time you level up as an entrepreneur. Take this chance to learn so you can earn!

Spot the Signs you have Diabetes

You could you be a victim of diabetes and not realize it.

Diabetes is a serious condition where in the body has too much glucose or blood sugar. This is caused by the body not producing insulin, not releasing enough insulin or the cells not responding to the insulin produced by the pancreas.

Insulin is essential for glucose to enter our cells. Without it, glucose remains in our blood which causes our blood sugar level to shoot up or down erratically. If left untreated or unattended, it could be worse. Have you heard about those whose legs or fingers were amputated because their wounds never healed? Or those who are suffering from the complications of diabetes such as stroke?

You definitely wouldn’t want to get to that point. Prevention, really, is better than cure! As early as possible, know if what you’re experiencing are symptoms of diabetes. Here are list of indications to watch out for.

1. Blurred vision
2. Frequent Urination
3. Intense thirst and hunger
4. Unusual weight loss or gain
5. Fatigue
6. Have wounds that do not or take time to heal
7. Snoring
8. Male erectile dysfunction
9. Numbness or tingling feeling in feet or hands
10. Loss of hearing
11. Random dark patches on skin

They may seem like just usual symptoms of mild illnesses but if you feel you’re not getting any better, it’s best to seek medical advice.

Health is hard and expensive to restore. Don’t let diabetes drain your pocket and your life. Protect yourself from this disease that develops life-threatening complications.

Royale’s Diabetwatch is a dietary supplement that helps prevent diabetes naturally. It contains essential herbal extracts that offer full prevention against diabetes:

• AMPALAYA EXTRACT: Has flavonoids and alkaloids to help the pancreas produce insulin, aids in sugar regulation, and source of Vitamins A, B, and C, iron, folic acid, phosphorus and calcium.

• BANABA EXTRACT: Contains high concentrations of dietary fiber and minerals such as zinc and magnesium. It helps fight obesity, is good for the kidney, and aids in the digestive system.

• TURMERIC: Consists of powerful antioxidants that have the ability to neutralize free radicals. It is a natural detoxifier that is anti-inflammatory and a natural pain reliever.

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Four Simple Tips to Get rid of your Beer Belly

As time marches on, some people will find that they are retaining a beer belly and let’s admit, whether you’re a man or woman, no one likes to have that bulging gut hanging from your beltline! Here are some techniques on how to get rid of that beer belly!

1. Get up and exercise

Stack some books or put some fruits in a durable plastic bag. Maybe a pail of water will do. Anything that weighs 10 kilograms or more, lift it. Lifting weights strengthen your muscles and boost your metabolism.

Another good idea is to endure some cardio training, even if you have to hire a personal trainer for the first week or so just to get you into proper motion, do just that!  Now, don’t think that a thirty-minute jog will cut it.  You are going to have to consistently get up and stay in motion for longer.

Start with the basics:

• Jumping jacks: For strength and endurance
• Squats and walking lunges: For building lower body muscles
• Pushups: For arm strength
• Sit-ups: For upper body strength

Doing these exercises keeps your blood pumping and your body sweating. That means, calories burning. By patiently and consistently following a routine, except that belly change in a matter of months. It might be hard, but it’s gonna be worth it.

2. Have Enough Sleep

It might be impossible to believe, but sleeping can actually help us lose weight. This is because when we sleep, our bodies produce a hormone called leptin. This hormone has the ability to keep our appetites and another hormone called ghrelin low. Ghrelin is the exact opposite of Leptin as it is responsible for stimulating our appetite.

The next time you decide to take a nap, don’t think that you are completely lacking the activity to lose weight. You are actually losing some.

3. Reduce Alcohol Consumption

It might sound awful, but you have to monitor how much alcohol you consume.  You cannot drink like it’s going out of style and not expect to blow up like a blimp.  Alcohol has quite a lot of sugar in each bottle and consuming too much of it will make you fat.

If you want to lose the beer belly, you will have to taper off your alcohol intake until you can finally get it down to only having one day set aside for drinking. It’s time you say yes to just “drinking occasionally in moderation.”

It helps to drink water in between glasses of liquor to keep you hydrated and to help increase your digestion.

4. Eat smart

You can’t just cut out most of the alcohol and then continue to eat processed, packaged, and salty foods.  It just doesn’t work that way; your body doesn’t work that way!  Your body, your mind, and your emotional status all play hand in hand and when you don’t change your eating habits your beer belly will forever be there.

Say goodbye to carbs and say hello to protein! Apparently, it has been proven that our cravings can be reduced up to 60% just by eating protein-rich food. So don’t just stop eating, eat right.

Here is a list of the basic protein-rich food that’s just around you.

• eggs
• chicken
• milk
• fish or any seafood

Of course, you can also seek the aid of dietary supplements to flatten back that beer belly faster.

Check out Royale Fastrim, a dietary supplement that combines the three natural ingredients known to be effective in managing weight the healthy way: L-Carnitine Tartrate; Green Tea Extract and Garcinia Cambogia.

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• L-Carnitine Tartrate promotes the optimal burning of fatty acids in the mitochondria to produce more energy.
• GREEN TEA EXTRACT is a powerful antioxidant which promotes weight loss by helping the body to burn calories.

• GARCINIA CAMBOGIA EXTRACT decreases our cravings for food by suppressing appetite signal to our brain, making it easier to eat less.

Take note, Royale Fastrim is not a magical supplement. It won’t work if you just rely on it entirely. It’s proven more effective with proper diet, exercise, and enough sleep.

If you realize that you might have drunk more than you should have, seeing that beer belly hanging low, say enough is enough! Trim down the unnecessary portions of your stomach. Look and feel better than ever with Royale Fastrim!

Do Coffee Drinkers Live Longer?

Almost everyone in the world loves coffee. Some would just occasionally take a sip; others make it a point to drink coffee on a regular basis.

Are you a hardcore coffee lover too?

Here is probably the best coffee benefit you’ve never heard of!

Can Coffee Really Add More Years to A Person’s Life?

According to a study published in the New England Journal of Medicine in 2012, adults who are coffee drinkers tend to live longer than those who don’t consume coffee on a regular basis.

The study observed adults between 50 to 71 years of age. Spanning over 12 to 13 years in the observation, the study found that those who drank a certain amount of coffee reduced their risk of death from known killer diseases compared to non-coffee drinkers. Among these conditions are heart disease and diabetes. 

Other Health Benefits of Drinking Coffee Daily

• Coffee can actually improve the energy levels of a person, as well as boost their brain power. This is because caffeine, when consumed will travel to the brain which will wedge the inhibitory neurotransmitter, which is called Adenosine.  A number of neurotransmitters, such as norepinephrine, as well dopamine will then begin to increase, which will lead to an enhancement of firing neurons.
• Drinking coffee daily can actually assist in burning calories! Studies show that caffeine can lift the metabolic rate by at least 3-11% and other studies have been calculated that caffeine can increase the burning of fat in obese persons by at least 10%.
• Coffee could very well, lower a person’s risk of type two Diabetes! In a recent study, it’s been proven that people who consume coffee actually hold a 23-50% lower risk of having diabetes.
• It’s a known fact that there are essential nutrients found in coffee! Believe it or not, but a single cup of coffee is known to contain the following nutrients: Riboflavin (Vitamin B2) 11% of the RDA.  Manganese and Potassium 3% of the RDA.  Pantothenic Acid (Vitamin B5) 6% of the RDA.  Magnesium and Niacin (B3) 2% of the RDA.

However, with all the given facts, you still need to consider the brand of coffee itself.

Don’t be deceived by the flavor, check out the content as well.

Royale’s Coffee Blend offers more health benefits than your average cup of coffee with its 8-in-1 premium blend. Packed with coffee, cream, and sugar, this premium drink is also powered by five other active ingredients, which guarantee a health boost in every sip!

• SPIRULINA: For nourishment
• GINSENG: For Energy
• GANODERMA: For longevity
• GRAPESEED: Against the early signs of aging
• AGARICUS BLAZEI MURILL: Against hypertension and cancer

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WATCH: The Chemical Reactions That Make Pizza Taste So Good

Pizza tastes even better when you understand the chemistry behind it - and it also helps you work out the best toppings for your next slice.

Whether it’s a plain cheese, a deep-dish stacked with meats or a thin-crust veggie delight, there’s just something about pizza that makes it delicious. There’s a lot of chemistry that goes into everything from dough to sauce to toppings to, of course, cheese. There’s also a very specific chemical reaction at work on every single slice, no matter what toppings you choose. It's called the Maillard Reaction, and it's what causes the browning of the dough and toppings, as well as the release of some delicious compounds.

In this video, the American Chemical Society explains the complex reactions that lead to pizza tasting the way it does - like a gooey, carby, cheesy, delicious slice of heaven.

Basically, it’s combination of an acidic tomato sauce, which should have a pH of around 4.0 to 4.6, the yeasty dough and the freshest cheese possible that elevates a slice from OK to amazing.

And for those who get acid reflux, the video suggests adding a little bit of baking soda to help balance out the acid.

Check it out above to find out more about how to scientifically create a great pizza, and why you should always cook your pizza at over 140 degrees Celsius.

You’re welcome.

Source: Reactions by the American Chemical Society 

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How to Write Email Subject Lines Like a Pro

When your email subscribers open their inbox, it’s like they enter a candy store. Dozens, even hundreds of treats are staring at them from the shelves. Your subject line is the candy wrap for your bon-bon; you’ve got to make sure it stands out, because the competition in this inbox candy store is fierce. How can you make sure your subscribers open your emails?

There are a few people whose emails I always open, even if I know they’re trying to sell me something and I don’t want to buy. They’ve refined the skill of subject line writing to a level that each of their emails is a shiny, tempting candy that I can’t help but unwrap.

Subject line mastery is a desired for any marketer, so I x-rayed my inbox for the best examples that I can learn from. My findings are below. I believe the following 5 marketers are pros when it comes to writing email subject lines.

• Ramit Sethi, I Will Teach You To Be Rich

Ramit is THE master of email marketing. His subject lines are intriguing, funny and real. His emails are always either amusing or educative or inspiring, so you know you’re going to get something valuable when you open his emails. Ramit is first and foremost a brilliant psychologist; he speaks the language of his subscribers and uses the exact phrases we’d use when talking about his topics. After a certain time on Ramit’s email list, you start feeling like you personally know him, and why not open an email from a friend? Here are a few of Ramit’s subject lines:

I’m so good with Asian Moms
When friends say, “Tell me if I ever get in a bad relationship...”
I got schooled
I LOL’d at this $300,000 comment
I recorded these for you
She said I sucked at love. I LOL’d.
Courage comes in surprising forms (like Chipotle)
“Why don’t babies in Asia cry?”
How to give advice so that people will listen
I ate too much
This woman spends $20,000/year on beauty

• Derek Halpern, Social Triggers

Derek Halpern’s got his own style. You can almost recognize him in your inbox just by looking at the subject line. He is uncompromisingly forthright; in his own words, he is “the loud New Yorker who will give it to you straight.” You know you’re going to learn something useful in every email, so you go along with it. Here are a few of Derek’s subject lines:

You’ll think I’m crazy...
17 unedited reasons why they joined Seven Figure Courses
Answer this real quick...
I hate these gimmicks
How to Email Important People (The Ebook)
the ONLY 3 “real” secrets to greatness
GREAT news (here’s why)
This is a little embarrassing...
Writing used to be hard. Then I tried this...
2015: Be The Exception

• Mariah Coz, Femtrepreneur

Mariah’s signature is focusing on you, the reader. You want to open her emails because they promise something specific to you personally, something that will help in your particular situation. She is also super honest about her business, her process and thoughts, and has an unapologetic no-BS tone, all of which builds trust. Here are a few of her subject lines:

Our time together tomorrow
Replay coming down and other sad news
You. Coffee. This replay + bundle...[time sensitive!]
Make them do a double take
Can you build your business without spending a penny on ads?
The one thing I’ve always struggled with...
The truth about my first $1000 month (it almost killed me)

• Charlie Hoehn

Charlie Hoehn is another example of an online marketer who knows what ticks, and he scratches exactly where it itches. He has learned from the best, having worked with Tim Ferriss, Ramit Sethi & Tucker Max. He looks deeper than most web marketers and understands his subscribers’ anxieties and fears, and his subject lines reflect that:

This email might change your life 🙌
are you kidding?
The bravest people I know
How to stop torturing yourself
How my friends earned $250,000 in one hour 😮 (no exaggeration)
Why I quit my dream job working for Tim Ferriss
Do this to feel normal again this weekend
Do you ever avoid making friends? (one more action item)

• Melyssa Griffin, The Nectar Collective

Melyssa always gives you something extra. Even if the email is a reminder for one of her webinars or courses, she starts with something else that gets readers to open the email. She is open and very generous with her knowledge and consistently over delivers value. Melyssa grabs readers’ attention with a very informal and friendly tone:

Why creating a “newsletter” is a mistake
Here’s what I wish someone had told me sooner... (replay is coming down today!!)
Can we get personal? I want to share something that happened to me today.
My biggest business mistake? It’s this... (plus another webinar added!)
My email list used to overwhelm me, too. But this was my turning point...
A free bootcamp to help you rock your email list and newsletter? Let’s do it.
3 bogus myths about growing your email list (free workshop SOON!)
It’s almost MARCH (whaaaa?). Are you where you want to be?
How to know if you’re ready to quit your day job [p.s. price goes up tomorrow]

Bottom Line

Each of the aforementioned marketers has their own style, but I’ve noticed a few common trends across the emails I analyzed. Many subject lines have a conversational tone, as if the email was coming from a friend. Many of them are either direct, intriguing, or personal. Others include an exact number or indicate scarcity.

Lastly, I want to note that all of the marketers I analyzed consistently deliver great value and that’s what makes their emails so great. Writing email subject lines is an important craft, but nothing will help your email marketing as much as knowing your audience and consistently delivering quality content.

Would you add someone to this list of subject line pros? Please share your thoughts in the comments.